Incorporation of 1-C14-linoleic acid into liver phospholipid fatty acid in albino rats with deficiency of fat and vitamin B6.

Linoleic acid (all cis) changes into arachidonic acid in the liver of rat. This is facilitated by vitamin Bo according to Holman et al.1-3 The authors confirmed this and further clarified the following facts .4 Such change from linoleic acid to arachidonic acid was more pronounced in the phospholipid of the liver. In the phospholipid, arachidonic acid changed into linoleic acid but vitamin B6 does not participate in it. Participation of vitamin B6 in the process of the change of linoleic acid into other fatty acids in the phospholipid of the liver was then studied. In rats with deficiency of fat and pyridoxine, C14-linoleic acid was administered to study the time course of fatty acid incorporation into liver phospholipid. The following results were obtained.